R18 TFA (Synonyms: PHCVPRDLSWLDLEANMCLP TFA) |
| Catalog No.GC61601 |
R18 TFA는 70-90nM의 KD를 갖는 14-3-3의 펩티드 길항제입니다. R18은 14-3-3의 생리학적 리간드인 키나제 Raf-1에 대한 14-3-3의 결합을 효율적으로 차단하고, Raf-1의 포스파타제 유도 불활성화에 대한 14-3-3의 보호 역할을 효과적으로 제거합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].
[1]. B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38(38):12499-504.
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