R18 TFA (Synonyms: PHCVPRDLSWLDLEANMCLP TFA) |
| カタログ番号GC61601 |
R18 TFA は 14-3-3 のペプチドアンタゴニストで、KD は 70-90 nM です。 R18 は、14-3-3 の生理学的リガンドであるキナーゼ Raf-1 への 14-3-3 の結合を効率的にブロックし、ホスファターゼによる Raf-1 の不活化に対する 14-3-3 の保護的役割を効果的に無効にしました。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].
[1]. B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38(38):12499-504.
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