Remogliflozin A (Synonyms: GSK189074) |
| Catalog No.GC18762 |
레모글리플로진 A는 인간 및 쥐 SGLT2에 대해 각각 12.4 및 26nM의 Kis를 갖는 SGLT2(나트륨-포도당 공동수송체 2)의 강력하고 선택적인 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 329045-45-6
Sample solution is provided at 25 µL, 10mM.
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Remogliflozin A is a potent inhibitor of sodium-glucose transporter 2 (SGLT2; Kis = 12.4 and 26 nM for human and rat SGLT2, respectively). It is selective for SGLT2 over SGLT1 (Kis = 4,520 and 997 nM for human and rat SGLT1, respectively). Following administration of a prodrug, remogliflozin etabonate, that is rapidly converted to remogliflozin A in vivo, rat urinary glucose excretion increases and plasma glucose and insulin concentrations decrease. Similar effects are observed following oral administration of remogliflozin etabonate to rats with diabetes induced by streptozotocin and db/db mice with hyperinsulinemia and obesity.
Review for Remogliflozin A
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
Review for Remogliflozin A
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