Remogliflozin A (Synonyms: GSK189074) |
| Catalog No.GC18762 |
Remogliflozin A is a potent and selective inhibitor of SGLT2 (sodium-glucose cotransporter 2) with Kis of 12.4 and 26 nM for human and rat SGLT2, respectively.
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Cas No.: 329045-45-6
Sample solution is provided at 25 µL, 10mM.
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Remogliflozin A is a potent inhibitor of sodium-glucose transporter 2 (SGLT2; Kis = 12.4 and 26 nM for human and rat SGLT2, respectively). It is selective for SGLT2 over SGLT1 (Kis = 4,520 and 997 nM for human and rat SGLT1, respectively). Following administration of a prodrug, remogliflozin etabonate, that is rapidly converted to remogliflozin A in vivo, rat urinary glucose excretion increases and plasma glucose and insulin concentrations decrease. Similar effects are observed following oral administration of remogliflozin etabonate to rats with diabetes induced by streptozotocin and db/db mice with hyperinsulinemia and obesity.
Review for Remogliflozin A
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
Review for Remogliflozin A
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