DHFR
Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate (H4F) utilizing nicotinamide adenine dinucleotide phosphate (NADPH) as the hydride (H-) donor, in which the pro-R hydrogen of NADPH is transferred to C6 of the pteridine ring with concomitant protonation at the N5 position. The functional DHFR gene (approximately 30 kb with six exons and five introns) has been identified to encode DHFR enzyme. Human DHFR enzyme is a monomeric protein of 186 amino acids, which is characterized by containing a highly conserved dinucleotide-binding domain consisting of seven parallel and one antiparallel β-strands intercalated by α-helices.
Products for DHFR
- Cat.No. 상품명 정보
- GC16333 Cycloguanil (hydrochloride) Proguanil의 활성 대사 산물인 Cycloguanil(염산염)은 적혈구와 간세포의 말라리아 분열에 작용합니다.
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GC10405
Methotrexate
폴레이트 억제제인 메토트렉세이트는 저농도로 매주 사용될 때 강력한 항염증 효과를 나타내며, 이는 염증된 부위에서 아데노신 분비가 증가함으로써 생기는 항염작용에 기인합니다.
- GC11610 Pemetrexed An antifolate with anticancer activity
- GC17694 Pemetrexed disodium hemipenta hydrate
- GC12919 Pralatrexate A dihydrofolate reductase inhibitor
- GC17867 Pyrimethamine A dihydrofolate reductase inhibitor