Roflupram |
| Catalog No.GC64522 |
Roflupram은 인간 PDE4의 핵심 촉매 도메인에 대한 IC50이 26.2nM인 선택적 경구 활성 뇌 침투 PDE4 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1093412-18-0
Sample solution is provided at 25 µL, 10mM.
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Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].
[1]. Li D, et, al. Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway. Int Immunopharmacol. 2021 Jan;90:107176. [2]. You T, et, al. Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci. 2017 Nov 15;8(11):2381-2392.
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