Roflupram |
| Katalog-Nr.GC64522 |
Roflupram ist ein selektiver, oral aktiver und in das Gehirn eindringender PDE4-Hemmer mit einem IC50-Wert von 26,2 nM fÜr katalytische KerndomÄnen von menschlicher PDE4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1093412-18-0
Sample solution is provided at 25 µL, 10mM.
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Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].
[1]. Li D, et, al. Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway. Int Immunopharmacol. 2021 Jan;90:107176. [2]. You T, et, al. Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci. 2017 Nov 15;8(11):2381-2392.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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