Sepimostat |
| Catalog No.GC61580 |
Sepimostat(FUT-187 유리 염기)는 NR2B 서브유닛의 Ifenprodil 결합 부위에서 NR2B N-메틸-D-아스파테이트 수용체 길항작용을 통해 신경보호 활성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 103926-64-3
Sample solution is provided at 25 µL, 10mM.
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Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].
Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. Animal Model: Male Sprague Dawley rats weighing 150-300 g[1].
[1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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