Sepimostat |
| カタログ番号GC61580 |
セピモスタット (FUT-187 遊離塩基) は、NR2B サブユニットのイフェンプロジル結合部位で NR2B N-メチル-D-アスパラギン酸受容体拮抗作用を介して神経保護活性を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 103926-64-3
Sample solution is provided at 25 µL, 10mM.
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Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].
Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. Animal Model: Male Sprague Dawley rats weighing 150-300 g[1].
[1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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