SM-6586 |
| Catalog No.GC32552 |
SM-6586은 칼슘 채널 길항제이자 Na+/H+ 및 Na+/Ca2+ 교환 수송의 억제제이며 잠재적으로 뇌혈관 질환 및 고혈압 치료에 사용됩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 103898-38-0
Sample solution is provided at 25 µL, 10mM.
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SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
In SM-6586-treated spontaneously hypertensive rats, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher and lactate level. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. The brain water content is significantly decreased in the SM-treated group[1].
[1]. Kashiwagi F, et al. Effect of a new calcium antagonist (SM-6586) on experimental cerebral ischemia. Acta Neurochir Suppl (Wien). 1994;60:289-92.
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