SM-6586 |
| Katalog-Nr.GC32552 |
SM-6586 ist ein Calciumkanalantagonist und Inhibitor des Na+/H+- und Na+/Ca2+-Austauschtransports, mÖglicherweise zur Behandlung von zerebrovaskulÄren Erkrankungen und Bluthochdruck.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 103898-38-0
Sample solution is provided at 25 µL, 10mM.
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SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
In SM-6586-treated spontaneously hypertensive rats, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher and lactate level. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. The brain water content is significantly decreased in the SM-treated group[1].
[1]. Kashiwagi F, et al. Effect of a new calcium antagonist (SM-6586) on experimental cerebral ischemia. Acta Neurochir Suppl (Wien). 1994;60:289-92.
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