Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) (Synonyms: HTI-286 trifluoroacetate; SPA-110 trifluoroacetate) |
Catalog No.GC34135 |
Taltobulin trifluoroacetate(HTI-286 trifluoroacetate)(HTI-286 trifluoroacetate)는 tripeptide hemiasterlin의 합성 유사체로서 시험관 내 및 생체 내에서 P-당단백질 매개 내성을 우회하는 강력한 항미세소관제입니다. Taltobulin trifluoroacetate(HTI-286 trifluoroacetate)는 정제된 튜불린의 중합을 억제하고 세포의 미세소관 조직을 파괴하며 유사분열 정지 및 세포자멸사를 유도합니다.
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Cas No.: 228266-41-9
Sample solution is provided at 25 µL, 10mM.
Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.IC50 value:Target: tubulinin vitro: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2].in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibited growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model [2].
[1]. Vashist YK, et al. Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin. World J Gastroenterol. 2006 Nov 14;12(42):6771-8. [2]. Hadaschik BA, et al. Targeting prostate cancer with HTI-286, a synthetic analog of the marine sponge product hemiasterlin. Int J Cancer. 2008 May 15;122(10):2368-76.
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