Tis108 |
Catalog No.GC19278
One-Click Copy Product Info
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Tis108은 트리아졸형 스트리골락톤(SL)-생물 합성 억제제이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1315459-30-3
Sample solution is provided at 25 µL, 10mM.
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Tis108은 트리아졸형 스트리골락톤(SL)-생물 합성 억제제이다.
Tis108(3㎛)은 Arabidopsis의 분기 수를 증가시키고 뿌리털의 신장을 억제하였다. Tis108(0, 0.2㎛, 1㎛, 5㎛)은 M26 재료(사과 수종, Malus pumila Mill.)의 목재식물의 새싹 재생 능력을 향상시키는 것으로 확인되었다. Tis108(10㎛; 5, 10, 30일)은 체리뿌리 수종의 줄기 성장과 발육을 촉진하고 체리뿌리 수종의 피질세포 크기를 증가시킨다.Tis108(10-100 nM)로 처리된 벼 유묘는 뿌리와 뿌리 분비물에서 트리아졸형 스트리골락톤(SL)의 수준을 농도 의존적으로 감소시킨다. Tis108(1㎛)로 처리된 벼 유묘의 뿌리 분비물은 대조 식물의 것에 비해 Striga의 발아에 대한 자극 효과가 더 약하다. Tis108(3㎛; 3주)은 면화의 Verticillium wilt에 대한 저항성을 감소시켰다.
References:
[1] Ito S, Umehara M, Hanada A, Yamaguchi S, Asami T. Effects of strigolactone-biosynthesis inhibitor TIS108 on Arabidopsis. Plant Signal Behav. 2013 May;8(5):e24193.
[2] Asghar S, Xiong Y, Che M, Fan X, Li H, Wang Y, Xu X, Li W, Han Z. Transcriptome analysis reveals the effects of strigolactone on shoot regeneration of apple. Plant Cell Rep. 2022 Jul;41(7):1613-1626.
[3] Liu X, Xu Y, Sun W, Wang J, Gao Y, Wang L, Xu W, Wang S, Jiu S, Zhang C. Strigolactones modulate stem length and diameter of cherry rootstocks through interaction with other hormone signaling pathways. Front Plant Sci. 2023 Feb 9;14:1092654.
[4] Ito S, Umehara M, Hanada A, Kitahata N, Hayase H, Yamaguchi S, Asami T. Effects of triazole derivatives on strigolactone levels and growth retardation in rice. PLoS One. 2011;6(7):e21723.
[5] Yi F, Song A, Cheng K, Liu J, Wang C, Shao L, Wu S, Wang P, Zhu J, Liang Z, Chang Y, Chu Z, Cai C, Zhang X, Wang P, Chen A, Xu J, Burritt DJ, Herrera-Estrella L, Tran LP, Li W, Cai Y. Strigolactones positively regulate Verticillium wilt resistance in cotton via crosstalk with other hormones. Plant Physiol. 2023 May 31;192(2):945-966.
| 식물 실험 [1]: | |
식물 모델 | Hai7124 |
제조 방법 | V.dahliae 포자 접종 24시간 전에 면화 묘목(Hai7124)는 Tis108 용액(3㎛)의 5mL 또는 동일한 부피의 물(동일한 양의 에탄올을 함유)로 토양을 적십니다. 감염 기간 동안 Tis108 또는 모의 대조 처리는 Tis108의 효과를 유지하기 위해 매주 두 번씩 적용됩니다. V.dahliae 감염 후 3주 동안 Tis108로 처리된 Hai7124 면화 묘목는 모의 대조 식물보다 더 심각한 병해 증상을 보였습니다. Tis108 처리 식물의 병해 지수는 대조 그룹과 비교해서 약 20% 증가했습니다. |
반응 조건 | 3μM; 3 주 동안 |
응용 분야 | Tis108(3㎛; 3주)은 면화의 Verticillium wilt에 대한 저항성을 감소시켰습니다. |
References: | |
| Cas No. | 1315459-30-3 | SDF | |
| Chemical Name | 6-phenoxy-1-phenyl-2-(1H-1,2,4-triazol-1-yl)hexan-1-one | ||
| Formula | C20H21N3O2 | M.Wt | 335.40 |
| Solubility | DMSO : ≥ 125 mg/mL (372.69 mM) | Storage | Store at -20℃ |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9815 mL | 14.9076 mL | 29.8151 mL |
| 5 mM | 596.3 μL | 2.9815 mL | 5.963 mL |
| 10 mM | 298.2 μL | 1.4908 mL | 2.9815 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)