Aurora Kinase Inhibitor II (Synonyms: 4-(4-Benzamidoanilino)-6,7-dimethoxyquinazoline) |
Catalog No.GC40667 |
Aurora Kinase Inhibitor II는 Aurora A 및 Aurora B에 대해 IC50이 각각 310nM 및 240nM인 선택적 및 ATP-경쟁적 Aurora 키나제 억제제입니다.
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Cas No.: 331770-21-9
Sample solution is provided at 25 µL, 10mM.
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 µM). In MCF-7 cells, it blocks proliferation with an IC50 value of 1.25 µM.
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