USP7-IN-8 |
| Catalog No.GC62377 |
USP7-IN-8(실시예 81)은 Ub-Rho110 분석에서 IC50이 1.4μM인 선택적 유비퀴틴 특이적 프로테아제 7(USP7) 억제제입니다. USP7-IN-8은 USP47 및 USP5에 대한 활동이 없음을 보여줍니다. USP7-IN-8은 항암 효과가 있습니다.
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Cas No.: 2009273-60-1
Sample solution is provided at 25 µL, 10mM.
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USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1].
USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].
[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.
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