USP7-IN-8 |
| カタログ番号GC62377 |
USP7-IN-8 (例 81) は、Ub-Rho110 アッセイで 1.4 μM の IC50 を持つ選択的ユビキチン特異的プロテアーゼ 7 (USP7) 阻害剤です。 USP7-IN-8 は、USP47 および USP5 に対して活性を示しません。 USP7-IN-8には抗がん効果があります。
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Cas No.: 2009273-60-1
Sample solution is provided at 25 µL, 10mM.
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USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1].
USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].
[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.
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