WDR5-IN-4 TFA |
| Katalog-Nr.GC61380 |
WDR5-IN-4 TFA ist ein Inhibitor der WIN-Stelle des Chromatin-assoziierten WD-Repeat-enthaltenden Proteins 5 (WDR5) mit einem Kd von 0,1 nM. WDR5-IN-4 TFA verdrÄngt WDR5 vom Chromatin und verringert die Expression assoziierter Gene, was zu Translationshemmung und nukleolÄrem Stress fÜhrt. Anti-Krebs-AktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].
[1]. Aho ER, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.
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