WZ8040 |
| Catalog No.GC11250 |
WZ8040은 비가역 돌연변이 EGFR T790M 억제제이며 EGFR 인산화를 억제합니다. WZ8040은 돌연변이 EGFR에 대해 정상보다 100배 더 큰 활성을 나타냅니다.
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Cas No.: 1214265-57-2
Sample solution is provided at 25 µL, 10mM.
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WZ8040 is a novel, irreversible mutant-selective EGFR kinase inhibitor that specifically inhibits phosphorylation of EGFRT790M.
WZ8040 shows to suppress the growth of EGFR T790M containing cell lines as well as inhibit phosphorylation of EGFR in the Non–Small-Cell Lung Cancer (NSCLC) cells. WZ8040 was identified from the screen that possessed up to a 300-fold lower IC50 against the PC9GR cells compared to clinical stage inhibitors such as HKI-272 [1].
References:
[1] Zhou W1, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature. 2009 Dec 24;462(7276):1070-4. doi: 10.1038/nature08622.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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