4-Hydroxymidazolam |
| Katalog-Nr.GC63628 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 59468-85-8
Sample solution is provided at 25 µL, 10mM.
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4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with sedative activities.
Midazolam is metabolized to 1’- and 4-hydroxymidazolam by CYP3A4 and CYP3A5 and is further metabolized to glucuronide conjugates by UDP-glucuronosyltransferases (UGTs)[1].
[1]. Seo KA, et al. Metabolism of 1’- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7. Drug Metab Dispos. 2010 Nov;38(11):2007-13.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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