4’-Chlorodiazepam |
| Katalog-Nr.GC64639 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14439-61-3
Sample solution is provided at 25 µL, 10mM.
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4'-Chlorodiazepam (Ro 5-4864), a benzodiazepine derivative of Diazepam, is a potent mitochondrial translocator protein 18kDa (TSPO) ligand. 4'-Chlorodiazepam shows neuroprotective effects[1][2].
4'-Chlorodiazepam is neuroprotective against amyloid-beta (Aβ) in SHSY-5Y neuroblastoma cells. Aβ decreases the cell viability of organotypic hippocampal cultures, while 4'-Chlorodiazepam has a neuroprotective effect when administered at 100nM and 1000nM. The neuroprotective effects of 4'-Chlorodiazepam against Aβ are associated with an increased expression of superoxide dismutase (SOD) [1].4'-Chlorodiazepam preserves cell viability and reduces nuclear fragmentation in glucose-deprived cells. These effects are accompanied by a reduced production of free radicals and maintenance of mitochondrial functions in cells treated with 4'-Chlorodiazepam[2].
[1]. B D Arbo, et al. 4'-Chlorodiazepam is neuroprotective against amyloid-beta in organotypic hippocampal cultures. J Steroid Biochem Mol Biol. 2017 Jul;171:281-287.
[2]. Eliana Baez, et al. 4'-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation. Neurotox Res. 2017 Aug;32(2):163-171.
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