5’-Phosphoguanylyl-(3’,5’)-guanosine |
| Katalog-Nr.GC63957 |
5’-Phosphoguanylyl-(3’,5’)-Guanosin (pGpG) ist ein intermediäres Molekül, das auf dem Weg des enzymatischen Abbaus von zyklischem Diguanylat (c-di-GMP) entsteht.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 33008-99-0
Sample solution is provided at 25 µL, 10mM.
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5’-Phosphoguanylyl-(3’,5’)-guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5’-Phosphoguanylyl-(3’,5’)-guanosine can be used to detect the metabolism of nucleic acids[1][2].
5’-Phosphoguanylyl-(3’,5’)-guanosine reduces the rate of c-di-GMP degradation in cell lysates and inhibits the activity of EAL-dependent PDEs (PA2133, PvrR, and purified recombinant RocR) from P. aeruginosa[2].
[1]. Nesbitt NM, et, al. Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate. Biotechnol Rep (Amst). 2015 May 5;7:30-37.
[2]. Cohen D, et, al. Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11359-64.
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