7-BIA |
| Katalog-Nr.GC65394 |
7-BIA ist ein Inhibitor der Protein-Tyrosin-Phosphatase D (PTPRD) vom Rezeptortyp mit einem IC50 von ~1-3 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1313403-49-4
Sample solution is provided at 25 µL, 10mM.
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7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1].
7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC50 values of ~1-3 μM and 40 μM, respectively[1].
7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice[1].
[1]. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosinephosphatase D (PTPRD) and by a novel PTPRD antagonist. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11597-11602.
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