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Abediterol (Synonyms: LAS100977; LAS-100977; LAS 100977; Abediterol)

Katalog-Nr.GB62190 Copy One-Click Copy Product Info

Abediterol, also known as LAS100977, is a novel potent, long-acting inhaled β(2)-adrenoceptor agonist in development for the treatment of asthma and chronic obstructive pulmonary disease.

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Abediterol Chemische Struktur

Cas No.: 915133-65-2

Größe Preis Lagerbestand Menge
1mg
150,00 $
Auf Lager
5mg
450,00 $
Auf Lager
10mg
750,00 $
Auf Lager
25mg
1.650,00 $
Auf Lager
50mg
2.950,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.



Description of Abediterol

Abediterol, also known as LAS100977, is a novel potent, long-acting inhaled β(2)-adrenoceptor agonist in development for the treatment of asthma and chronic obstructive pulmonary disease. Abediterol shows subnanomolar affinity for the human β(2)-adrenoceptor and a functional selectivity over β(1)-adrenoceptors higher than that of formoterol and indacaterol in both a cellular model with overexpressed human receptors and isolated guinea pig tissue. Abediterol is a full agonist at the human β(2)-adrenoceptor (E(max) = 91 ± 5% of the maximal effect of isoprenaline). The potency and onset of action that abediterol shows in isolated human bronchi (EC(50) = 1.9 ± 0.4 nM; t½ onset = 7-10 min) is not significantly different from that of formoterol, but its duration of action (t½ ∼ 690 min) is similar to that of indacaterol.

Chemical Properties of Abediterol

Cas No. 915133-65-2 SDF
Überlieferungen LAS100977; LAS-100977; LAS 100977; Abediterol
Canonical SMILES O=C1NC2=C(C([C@@H](O)CNCCCCCCOCC(F)(F)C3=CC=CC=C3)=CC=C2O)C=C1
Formula C25H30F2N2O4 M.Wt 460.5218
Löslichkeit Soluble in DMSO, not in water Storage Store at-20℃
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Abediterol

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.1714 mL 10.8572 mL 21.7145 mL
5 mM 434.3 μL 2.1714 mL 4.3429 mL
10 mM 217.1 μL 1.0857 mL 2.1714 mL
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In vivo Formulation Calculator (Clear solution) of Abediterol

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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