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AM3102 (Synonyms: KDS5104)

Katalog-Nr.GC18365 Copy One-Click Copy Product Info

A potent PPARα agonist

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AM3102 Chemische Struktur

Cas No.: 213182-22-0

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5mg
68,00 $
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10mg
129,00 $
Auf Lager
50mg
525,00 $
Auf Lager
100mg
916,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.



Description of AM3102

Oleoyl ethanolamide (OEA) is an endogenous agonist for proliferator-activated receptor α (PPARα) that suppresses food intake, promotes lipolysis, and reduces weight gain in rodents. The biological effects of OEA are terminated by fatty-acid amide hydrolase and N-acylethanolamine-hydrolyzing acid amidase. AM3102 is an OEA analog that stimulates PPARα transcriptional activity with an EC50 value of 100 nM and prolongs feeding latency in rodents with an ED50 value of 2.4 mg/kg. It is resistant to enzymatic hydrolysis and is as potent as OEA in enhancing transcriptional activity of PPARα and reducing food intake in free-feeding rats. AM3102 demonstrates weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 33 and 26 uM, respectively.

Chemical Properties of AM3102

Cas No. 213182-22-0 SDF
Überlieferungen KDS5104
Chemical Name N-[(1R)-2-hydroxy-1-methylethyl-9Z-octadecenamide
Canonical SMILES OC[C@@H](C)NC(CCCCCCC/C=C\CCCCCCCC)=O
Formula C21H41NO2 M.Wt 339.6
Löslichkeit DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of AM3102

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.9446 mL 14.7232 mL 29.4464 mL
5 mM 588.9 μL 2.9446 mL 5.8893 mL
10 mM 294.5 μL 1.4723 mL 2.9446 mL
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In vivo Formulation Calculator (Clear solution) of AM3102

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Review for AM3102

Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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