APX2039 |
| Katalog-Nr.GC64848 |
APX2039 ist ein oral aktiver und potenter Inhibitor des pilzlichen Gwt1-Enzyms.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2342606-49-7
Sample solution is provided at 25 µL, 10mM.
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APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research[1][2].
[1]. Karen J Shaw, et al. 168. Efficacy of the Novel gwt1 Inhibitor APX2039 in a Rabbit Model of cryptococcus Meningitis. Open Forum Infect Dis. 2020 Dec 31.
[2]. Yu CH, et al. Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System. mBio. 2021 Dec 21;12(6):e0231321.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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