AR-A 2 (AR-A 000002) (Synonyms: AR-A 000002) |
| Katalog-Nr.GC31291 |
AR-A 2 (AR-A 000002) ist ein selektiver 5-HT1B-Rezeptorantagonist mit hoher AffinitÄt zu Meerschweinchen-Cortex-5HT1B/1D- und rekombinanten Meerschweinchen-5-HT1B-Rezeptoren (Ki=0,24 und 0,47 nM) und mit 10-facher AffinitÄt geringere AffinitÄt zum Meerschweinchen-5-HT1D-Rezeptor (Ki, 5 nM) und zeigt eine EC50 von 4,5 nM fÜr den Meerschweinchen-5-HT1B-Rezeptor; AR-A 2 (AR-A 000002) kann in der Depressions- und Angstforschung eingesetzt werden.
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Cas No.: 220051-79-6
Sample solution is provided at 25 µL, 10mM.
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AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety.
AR-A 2 (AR-A000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptors (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor. AR-A 2 also binds to the rat cortical 5HT1B/1D receptor (Ki, 20 nM), rat cortex 5-HT2A receptor (Ki, 339 nM), rat hippocampus 5-HT1A receptor (Ki, 3070 nM). In addition, AR-A 2 also exhibits affinity for dopamine D2 (Ki, 330 nM) and α1-adrenoceptors (Ki, 490 nM)[1].
[1]. Ahlgren C, et al. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist. Eur J Pharmacol. 2004 Sep 19;499(1-2):67-75.
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