Argipressin (acetate) (Synonyms: AVP, Arg8-Vasopressin) |
Katalog-Nr.GC48997
One-Click Copy Product Info
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A peptide hormone with vasoconstrictive and antidiuretic activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 129979-57-3
Sample solution is provided at 25 µL, 10mM.
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Argipressin is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively.1,2 It also stimulates the intracellular release of calcium in A7r5 cells (EC50 = 5 nM).3 In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.4,5
1.Thibonnier, M., Bayer, A.L., Simonson, M.S., et al.Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cellsEndocrinology129(6)2845-2856(1991) 2.Xu, Y.J., and Gopalakrishnan, V.Vasopressin increases cytosolic free [Ca2+] in the neonatal rat cardiomyocyte. Evidence for V1 subtype receptorsCirc. Res.69(1)239-245(1991) 3.Byron, K.L.Vasopressin stimulates Ca2+ spiking activity in A7r5 vascular smooth muscle cells via activation of phospholipase A2Circ. Res.78(5)813-820(1996) 4.Gao, L., Jiang, N.-C., Luo, Q.-H., et al.Cardiovascular effects of injection of argipressin into lateral septal nuclei in ratsZhongguo Yao Li Xue Bao.17(1)49-52(1996) 5.Jiang, N.-C., Gao, L., Chen, C., et al.Effects of argipressin injected into medial amygdaloid body on blood pressure and heart rate in ratsZhongguo Yao Li Xue Bao.14(2)118-120(1993)
| Cas No. | 129979-57-3 | SDF | |
| Überlieferungen | AVP, Arg8-Vasopressin | ||
| Canonical SMILES | N[C@@H](CSSC[C@@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N)=O)=O)CCCNC(N)=N)=O)=O)NC([C@H](CC(N)=O)N2)=O)C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCC(N)=O)C2=O)=O)=O)=O.CC(O)=O | ||
| Formula | C46H65N15O12S2·XC2H4O2 | M.Wt | 1084.2 |
| Löslichkeit | Water: 1 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 922.3 μL | 4.6117 mL | 9.2234 mL |
| 5 mM | 184.5 μL | 922.3 μL | 1.8447 mL |
| 10 mM | 92.2 μL | 461.2 μL | 922.3 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A lyophilized powder
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)