Atomoxetine |
| Katalog-Nr.GC41535 |
Atomoxetin (Tomoxetin) ist ein selektiver Noradrenalin-Wiederaufnahmehemmer mit Ki-Werten von 5, 77 und 1451 nM fÜr Norepinephrin (NE), Serotonin (5-HT) bzw. Dopamin (DA) Transporter.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 83015-26-3
Sample solution is provided at 25 µL, 10mM.
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Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively. It is selective over the choline, GABA, and adenosine transporters, and a number of neurotransmitter receptors, ion channels, second messengers, and brain/gut peptides. In the rat prefrontal cortex (PFC), it increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression. Atomoxetine (0.1, 0.5, and 1 mg/kg) reduces premature responding, a measure of impulsivity, by rats in the 5-choice serial reaction time test (5CSRTT) in a dose-dependent manner. It also has neuroprotective effects when administered prior to ischemic damage in a gerbil model of transient cerebral ischemia. Formulations containing atomoxetine have been used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children, adolescents, and adults.
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