AZD-9833 (Synonyms: AZD-9833) |
| Katalog-Nr.GC60066 |
AZD-9833 (AZD-9833) ist ein potenter und oral aktiver Östrogenrezeptor (ER)-Antagonist. AZD-9833 wird fÜr die Studie von ER+ HER2-fortgeschrittenem Brustkrebs verwendet.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2222844-89-3
Sample solution is provided at 25 µL, 10mM.
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Estrogen receptor antagonist 2 is a potent and orally active estrogen receptor (ER) antagonist, example 17, extracted from patent US20180111931A1. Estrogen receptor antagonist 2 is used for the study of breast cancer[1].
Estrogen receptor antagonist 2 (oral administration; 0.2-50 mg/kg; 20 days) exhibits anti-tumour efficacy as a dose-dependent manner in human parental MCF7 mice xenograft[1].Estrogen receptor antagonist 2 (oral administration; 0.8-40 mg/kg; 30 days) decreases tumor growth as a dose-dependent manner. It gives almost complete tumour growth inhibition at the doses >10 mg/kg in mice[1]. Animal Model: Human ESR1 mutant breast cancer patient derived xenograft with CTC174 cells in female NSG mice[1]
[1]. Bernard Christophe Barlaam, etal. Chemical compounds. Patent US20180111931.
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