Bak BH3 (72-87) (human) (trifluoroacetate salt) |
Katalog-Nr.GC52344 |
A Bak-derived peptide
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Bak BH3 (72-87) is a peptide that corresponds to amino acids 72-87 of the pro-apoptotic protein Bak.1 It selectively binds to Bcl-xL over Bcl-2 (EC50s = 174 and 3,020 nM, respectively). Bak BH3 (72-87) induces apoptosis in LLC-PK1 porcine kidney epithelial cells.2
1.Frey, V., Viaud, J., Subra, G., et al.Structure-activity relationships of Bak derived peptides: Affinity and specificity modulations by amino acid replacementEur. J. Med. Chem.43(5)966-972(2008) 2.Peherstorfer, E., Mayer, B., Boehm, S., et al.Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cellsAm. J. Physiol. Renal. Physiol.283(1)F190-F196(2002)
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