Belvarafenib (Synonyms: GDC-5573, HM95573) |
Katalog-Nr.GC32950 |
Belvarafenib (HM95573) ist ein potenter und pan-Inhibitor von RAF (Rapidly Accelerated Fibrosarcoma) mit IC50-Werten von 56 nM, 7 nM und 5 nM fÜr B-RAF, B-RAFv600E bzw. C-RAF.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1446113-23-0
Sample solution is provided at 25 µL, 10mM.
Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].
[1]. WO 2013/100632 A1.
Average Rating: 5
(Based on Reviews and 14 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *