BIM-23190 hydrochloride |
| Katalog-Nr.GC62381 |
BIM-23190-Hydrochlorid, ein Somatostatin-Analogon, ein selektiver SSRT2- und SSRT5-Agonist, weist Ki-Werte von 0,34 nM und 11,1 nM fÜr SSTR2 bzw. SSTR5 auf. BIM-23190 kann in der Studie fÜr Krebs und Akromegalie verwendet werden.
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Sample solution is provided at 25 µL, 10mM.
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BIM-23190 hydrochloride, a somatostatin analog, a selective SSRT2 and SSRT5 agonist, exhibits Ki values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly[1][3].
BIM-23190 tends to mildly stimulate PRL secretion[1].
BIM-23190 (50 μg/mouse, twice a day) exhibits significant anti-tumor (C6 glioma) activity[2].
[1]. I Shimon, et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997 Nov 1;100(9):2386-92.
[2]. Federica Barbieri, et al. Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1078-88.
[3]. T J Gillespie, et al. Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution. J Pharmacol Exp Ther. 1998 Apr;285(1):95-104.
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