C20 Ceramide (d18:1/20:0) (Synonyms: Cer(d18:1/20:0)) |
| Katalog-Nr.GC43067 |
Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway.
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Cas No.: 7344/2/7
Sample solution is provided at 25 µL, 10mM.
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Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway. Certain forms of ceramide have been shown to mediate cellular responses such as apoptosis, growth arrest, and differentiation in certain cell types.[1][2] C20 Ceramide is a natural 20:0 ceramide that is abundant in the brain. It is synthesized de novo by ceramide synthases 1 and 2.[3][4]
Reference:
[1]. Ogretmen, B., Pettus, B.J., Rossi, M.J., et al. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A547 human lung adenocarcinoma cell line. J. Biol. Chem. 277(15), 12960-12969 (2002).
[2]. Pandey, S., Murphy, R.F., and Agrawal, D.K. Recent advances in the immunobiology of ceramide. Exp.Mol.Pathol. 82(3), 298-309 (2007).
[3]. Cowart, L.A. Sphingolipids: Players in the pathology of metabolic disease. Trends in Endocrinology and Metabolism 20(1), 34-42 (2008).
[4]. Pewzner-Jung, Y., Ben-Dor, S., and Futerman, A.H. When do lasses (longevity assurance genes) become CerS (ceramide synthases)? The Journal of Biological Chemisty 281(35), 25001-25005 (2006).
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