C24 Ceramide (d18:1/24:0) (Synonyms: C24 Ceramide) |
| Katalog-Nr.GC43074 |
C24 Ceramide (d18:1/24:0) is a natural ceramide (Cer) with a long acyl chain of 24 carbon units.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 34435-05-7
Sample solution is provided at 25 µL, 10mM.
C24 Ceramide (d18:1/24:0) is a natural ceramide (Cer) with a long acyl chain of 24 carbon units[1]. C24 Ceramide (d18:1/24:0) is a sphingomyelin (SM) that can be used to form lipid membranes[2]. C24 Ceramide (d18:1/24:0) can induce time-dependent changes in membrane properties and promote strong changes in vesicle shape[3]. The production of C24 Ceramide (d18:1/24:0) can promote spontaneous neutrophil apoptosis[4]. C24 Ceramide (d18:1/24:0) can be used as an internal standard in liquid chromatography-mass spectrometry (LC-MS) to quantify ceramide from animal samples[5]. C24 Ceramide (d18:1/24:0) can be used as a potential biomarker to distinguish metabolically healthy obesity (MHO) from metabolically unhealthy obesity (MUO)[6].
References:
[1] Pullmannová P, Pavlíková L, Kováčik A, et al. Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains[J]. Biophysical chemistry, 2017, 224: 20-31.
[2] González-Ramírez E J, García-Arribas A B, Sot J, et al. C24: 0 and C24: 1 sphingolipids in cholesterol-containing, five-and six-component lipid membranes[J]. Scientific Reports, 2020, 10(1): 14085.
[3] Ventura A E, Varela A R P, Dingjan T, et al. Lipid domain formation and membrane shaping by C24-ceramide[J]. Biochimica et Biophysica Acta (BBA)-Biomembranes, 2020, 1862(10): 183400.
[4] Seumois G, Fillet M, Gillet L, et al. De novo C16-and C24-ceramide generation contributes to spontaneous neutrophil apoptosis[J]. Journal of Leucocyte Biology, 2007, 81(6): 1477-1486.
[5] Kauhanen D, Sysi-Aho M, Koistinen K M, et al. Development and validation of a high-throughput LC–MS/MS assay for routine measurement of molecular ceramides[J]. Analytical and bioanalytical chemistry, 2016, 408: 3475-3483.
[6] Yu B, Hu M, Jiang W, et al. Ceramide d18: 1/24: 1 as a potential biomarker to differentiate obesity subtypes with unfavorable health outcomes[J]. Lipids in Health and Disease, 2023, 22(1): 166.
| Cas No. | 34435-05-7 | SDF | |
| Überlieferungen | C24 Ceramide | ||
| Chemical Name | N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-tetracosanamide | ||
| Canonical SMILES | CCCCCCCCCCCCCCCCCCCCCCCC(N[C@H](CO)[C@@H](O)/C=C/CCCCCCCCCCCCC)=O | ||
| Formula | C42H83NO3 | M.Wt | 650.1 |
| Löslichkeit | Chloroform: slightly soluble; Methanol: slightly soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.5382 mL | 7.6911 mL | 15.3822 mL |
| 5 mM | 307.6 μL | 1.5382 mL | 3.0764 mL |
| 10 mM | 153.8 μL | 769.1 μL | 1.5382 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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