Isoviolanthin |
| Katalog-Nr.GC36349 |
Isoviolanthin, ein Flavonoidglykosid, kÖnnte die TGF-β1-vermittelte Migration und Invasion deutlich hemmen, indem es die epithelial-mesenchymale Transition (EMT) Über die TGF-β/Smad- und PI3K/Akt/mTOR-Wege in HCC-Zellen deaktiviert. Isoviolanthin zeigt keine zytotoxischen Wirkungen auf normale Leber-LO2-Zellen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 40788-84-9
Sample solution is provided at 25 µL, 10mM.
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Isoviolanthin is a flavonoid glycoside extracted from the leaves of Dendrobium officinale. Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells but exhibits no cytotoxic effects on normal live cells, and has potential as a therapeutic agent for the treatment of advanced-stage metastatic HCC[1].
[1]. Xing S, et al. Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial?Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. Int J Mol Sci. 2018 May 23;19(6).
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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