(S)-(+)-Clopidogrel-d3 (sulfate) |
| Katalog-Nr.GC46346 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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(S)-(+)-Clopidogrel-d3 is intended for use as an internal standard for the quantification of (S)-(+)-clopidogrel by GC- or LC-MS. (S)-(+)-Clopidogrel is the functional enantiomer of clopidogrel and a prodrug whose thiol metabolite antagonizes purine binding to the platelet purinergic receptor P2Y12 (Ki = 316 nM in human platelets).1 It is metabolized by the cytochrome P450 (CYP) isoform CYP2C19 in rat liver and inhibits ADP-induced platelet aggregation ex vivo.2 Formulations containing (S)-(+)-clopidogrel have been used in combination with aspirin to prevent vascular ischemic events in patients with acute coronary syndromes.
1.Savi, P., Labouret, C., Delesque, N., et al.P2Y12, a new platelet ADP receptor, target of clopidogrelBiochem. Bioph. Res. Commun.283(2)379-383(2001) 2.Quinn, M.J., and Fitzgerald, D.J.Ticlopidine and clopidogrelCirculation100(15)1667-1672(1999)
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