C18 Ganglioside GM2-d3 (d18:1/18:0-d3) (ammonium salt) (Synonyms: C18 GM2-d3, N-omega-CD3-Octadecanoyl monosialoganglioside GM2, Monosialoganglioside GM2-d3, N-Stearoyl Monosialoganglioside GM2-d3) |
Katalog-Nr.GC46993 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
C18 Ganglioside GM2-d3 is intended for use as an internal standard for the quantification of ganglioside GM2 by GC- or LC-MS. C18 Ganglioside GM2 is a monosialylated ganglioside found in the mammalian brain where it is localized to the cell membrane.1 It accumulates in Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively.2 Ganglioside GM2 disrupts the function of immune cells and, when used at a concentration of 25 µM, increases migration and invasion of SK-RC-45 cells with no effect on proliferation.3 [Matreya, LLC. Catalog No. 2051]
1.Schnaar, R.L.Gangliosides of the vertebrate nervous systemJ. Mol. Biol.428(16)3325-3336(2016) 2.Baek, R.C., Martin, D.R., Cox, N.R., et al.Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff diseaseLipids44(3)197-205(2009) 3.Kundu, M., Mahata, B., Banerjee, A., et al.Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathwayBiochim. Biophys. Acta.1863(7 Pt A)1472-1489(2016)
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