CAY10742 |
| Katalog-Nr.GC47052 |
An oxadiazole antibiotic
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1649473-91-5
Sample solution is provided at 25 µL, 10mM.
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CAY10742 is an orally bioavailable oxadiazole antibiotic.1 It is active against the Gram-positive bacteria S. aureus, S. epidermidis, S. haemolyticus, B. cereus, B. licheniformis, E. faecalis, and E. faecium (MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin-resistant S. aureus (MRSA) infection.
1.Boudreau, M.A., Ding, D., Meisel, J.E., et al.Structure-activity relationship for the oxadiazole class of antibacterialsMed. Chem. Lett.11(3)322-326(2019)
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