Dexamethasone-d4 |
| Katalog-Nr.GC47202 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2483831-63-4
Sample solution is provided at 25 µL, 10mM.
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Dexamethasone-d4 is intended for use as an internal standard for the quantification of dexamethasone by GC- or LC-MS. Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).1 Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.2
1.Mulatero, P., Panarelli, M., Schiavone, D., et al.Impaired cortisol binding to glucocorticoid receptors in hypertensive patientsHypertension30(5)1274-1278(1997) 2.Beck, I.M., Vanden Berghe, W., Vermeulen, L., et al.Crosstalk in inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatasesEndocr. Rev.30(7)830-882(2009)
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