Dodecanoyl D-Sucrose (Synonyms: Sucrose monolaurate)

Dodecanoyl D-sucrose is a nonionic surfactant.¹ It is active against B. cereus, B. subtilis, S. aureus, E. coli, and S. typhimurium in a disc diffusion assay when used at a concentration of 255 mM. Transcutaneous immunization of mice with dodecanoyl D-sucrose-coated ovalbumin increases serum IgG levels by 5-fold compared to immunization with uncoated ovalbumin.² Topical administration of a dodecanoyl D-sucrose hydrogel (15% v/v) containing estradiol increases serum estradiol levels in rabbits compared to an ethanol-containing hydrogel.³ Dodecanoyl D-sucrose has been used to prepare stable foams in aqueous solutions, as well as oil-in-water emulsions.⁴

1.Zhao, L., Zhang, H., Hao, T., et al.In vitro antibacterial activities and mechanism of sugar fatty acid esters against five food-related bacteriaFood Chem.187370-377(2015) 2.Kitaoka, M., Imamura, K., Hirakawa, Y., et al.Sucrose laurate-enhanced transcutaneous immunization with a solid-in-oil nanodispersionMedChemComm.5(1)20-24(2014) 3.Vermeire, A., De Muynck, C., Vandenbossche, G., et al.Sucrose laurate gels as a percutaneous delivery system for oestradiol in rabbitsJ. Pharm. Pharmacol.48(5)463-467(1996) 4.Zhang, X., Wei, W., Cao, X., et al.Characterization of enzymatically prepared sugar medium-chain fatty acid monoestersJ. Sci. Food Agric.95(8)1631-1637(2015)