Terbinafine-d3 (hydrochloride) (Synonyms: TDT 067-d3 hydrochloride)

Terbinafine-d₃ is intended for use as an internal standard for the quantification of terbinafine by GC- or LC-MS. Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. mentagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC₅₀s = 0.003-0.8 μg/ml).¹ It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC₅₀s = 0.03 and 77 μM, respectively).² Terbinafine (90-120 µM) induces cell cycle arrest at the G₀/G₁ phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs).^3,4 Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections.

1.Petranyi, G., Meingassner, J.G., and Mieth, H.Antifungal activity of the allylamine derivative terbinafine in vitroAntimicrob. Agents Chemother.31(9)1365-1368(1987) 2.Ryder, N.S., and Dupont, M.C.Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymesBiochem. J.230(3)765-770(1985) 3.Lee, W.S., Chen, R.J., Wang, Y.J., et al.In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrestInternational Journal of Cancer106125-137(2003) 4.Ho, P.Y., Liang, Y.C., Ho, Y.S., et al.Inhibition of human vascular endothelial cells proliferation by terbinafineInternational Journal of Cancer11151-59(2004)