Urdamycin A (Synonyms: Antibiotic A 32Y2, Kerriamycin B, NSC 372208, NSC 606397) |
| Katalog-Nr.GC48226 |
A bacterial metabolite
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 98474-21-6
Sample solution is provided at 25 µL, 10mM.
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Urdamycin A is a bacterial metabolite originally isolated from S. fradiae that has antibacterial and anticancer activities.1,2 It is active against a variety of Gram-positive and Gram-negative bacteria, including B. subtilis and strains of Arthrobacter and Streptomyces, but not the fungus S. cerevisiae, in a disc assay when used at a concentration of 1 mg/ml.2 Urdamycin A is cytotoxic to L1210 and HT-29, but not A549, cancer cells (IC50s = 7.5, 5, and >10 µg/ml, respectively).1
1.Henkel, T., Ciesiolka, T., Rohr, J., et al.Urdamycins, new angucycline antibiotics from Streptomyces fradiae. V. Derivatives of urdamycin AJ. Antibiot. (Tokyo)42(2)299-311(1989) 2.Drautz, H., ZÄhner, H., Rohr, J., et al.Metabolic products of microorganisms. 234. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. I. Isolation, characterization and biological propertiesJ. Antibiot. (Tokyo)39(12)1657-1669(1986)
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