ω-3 Arachidonic Acid-d8 (Synonyms: ω3 AAd8)

ω-3 Arachidonic acid-d₈ contains eight deuterium atoms at the 8, 9, 11, 12, 14, 15, 17, and 18 positions. It is intended for use as an internal standard for the quantification of ω-3 arachidonic acid by GC- or LC-mass spectrometry. ω-3 Arachidonic acid is a rare polyunsaturated fatty acid found in trace amounts in dietary sources. ω-3 fatty acids are now known to be essential for infant growth and development and to protect against heart disease, thrombosis, hypertension, and inflammatory and autoimmune disorders.¹ In human platelet membranes, ω-3 arachidonic acid inhibits arachidonoyl-CoA synthetase with a K_i value of 14 µM. It also inhibits arachidonoyl-CoA synthetase in calf brain extracts with an IC₅₀ value of about 5 µM.²

1.Neufeld, E.J., Sprecher, H., Evans, R.W., et al.Fatty acid structural requirements for activity of arachidonoyl-CoA synthetaseJournal of Lipid Research25288-293(1984) 2.Simopoulos, A.P.Omega-3 Fatty acids in health and disease and in growth and developmentAmerican Journal of Clinical Nutrition54438-463(1991)