NS 383 |
| Katalog-Nr.GC50678 |
NS 383 ist ein potenter und einzigartig selektiver Inhibitor von Ratten-ASICs, die 1a und/oder 3 Untereinheiten enthalten.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 309711-59-9
Sample solution is provided at 25 µL, 10mM.
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ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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