UGT8 Inhibitor 19 (Synonyms: Ceramide Galactosyltransferase Inhibitor 19, CGT Inhibitor 19, UDP-galactose Ceramide Galactosyltransferase Inhibitor 19) |
| Katalog-Nr.GC49035 |
An inhibitor of UGT8
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Cas No.: 2414349-93-0
Sample solution is provided at 25 µL, 10mM.
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UGT8 inhibitor 19 is an inhibitor of UDP-galactose ceramide galactosyltransferase (UGT8), also known as ceramide galactosyltranferase (CGT; IC50 = 0.2 nM).1 It is selective for UGT8 over UGT1A1, -1A6, -2B7, -2B15, and -2B17 (IC50s = >10 µM for all). In vivo, UGT8 inhibitor 19 inhibits the synthesis of galactosylceramide (GalCer) and sulfatide (SFT) in juvenile mouse brain (ED50s = <3 mg/kg for both) and adult mouse kidney when administered at doses of 3, 10, and 30 mg/kg.
1.Burton, M.A., Antoun, E., Penailillo, R.S., et al.Folic acid induces intake-related changes in the mammary tissue transcriptome of C57BL/6 miceNutrients12(9)2821(2020)
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