Norcholic Acid (Synonyms: 23-Norcholic Acid) |
| Katalog-Nr.GC49323 |
NorcholsÄure ist eine normale kleine GallensÄure C23 mit vier Seitenketten und kommt in menschlichem Urin und Mekonium vor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60696-62-0
Sample solution is provided at 25 µL, 10mM.
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Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1 Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4
1.Nakatomi, F., Kihira, K., Kuramoto, T., et al.Intestinal absorption and metabolism of norcholic acid in ratsJ. Pharmacobiodyn8(7)557-563(1985) 2.Bremmelgaard, A., and SjÖvall, J.Bile acid profiles in urine of patients with liver diseasesEur. J. Clin. Invest.9(5)341-348(1979) 3.Kuramoto, T., Furukawa, Y., Nishina, T., et al.Identification of short side chain bile acids in urine of patients with cerebrotendinous xanthomatosisJ. Lipid Res.101895-1902(1990) 4.Pilo de la Fuente, B., Sobrido, M.J., GirÓs, M., et al.Usefulness of cholestanol levels in the diagnosis and follow-up of patients with cerebrotendinous xanthomatosisNeurologia26(7)397-404(2011)
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