α-Cortolone (Synonyms: 20α-Cortolone, NSC 59872) |
| Katalog-Nr.GC49838 |
A metabolite of cortisol
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 516-42-7
Sample solution is provided at 25 µL, 10mM.
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α-Cortolone is a metabolite of the glucocorticoid cortisol .1 It is formed from cortisol by 20α-hydroxysteroid dehydrogenase (20α-HSD) via a tetrahydrocortisone intermediate. Urinary levels of α-cortolone are decreased in patients with severe anorexia nervosa and in postmenopausal women with endometrial adenocarcinoma compared to postmenopausal women without endometrial adenocarcinoma.2,3
1.Espiard, S., McQueen, J., Sherlock, M., et al.Improved urinary cortisol metabolome in Addison disease: A prospective trial of dual-release hydrocortisoneJ. Clin. Endocrinol. Metab.106(3)814-825(2021) 2.Wassif, W.S., McLoughlin, D.M., Vincent, R.P., et al.Steroid metabolism and excretion in severe anorexia nervosa: Effects of refeedingAm. J. Clin. Nutr.93(5)911-917(2011) 3.Bufa, A., BÍrÓ, I., PoÓr, V., et al.Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometriiGynecol. Endocrinol.26(1)10-15(2010)
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