Idoxuridine (Synonyms: 5-iodo-2′-deoxyuridine, NSC 39661, SKF 14287) |
| Katalog-Nr.GC13247 |
Idoxuridin (5-Iod-2′-desoxyuridin, 5-IUdR, IdUrd) ist ein jodiertes Thymidin-Analogon, das Phosphorylasen kompetitiv hemmt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 54-42-2
Sample solution is provided at 25 µL, 10mM.
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Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster.
References:
[1]. Seth AK, et al. Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.Pharm Dev Technol. 2004 Aug;9(3):277-89.
[2]. Fauth E, et al. Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting. Mutat Res. 1999 Apr 6;440(2):147-56.
[3]. Otto SE. Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7.
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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