Cytidine 5-triphosphate |
Katalog-Nr.GC10665 |
Cytidin-5′-triphosphat (Cytidintriphosphat; 5′-CTP) ist ein Nukleosidtriphosphat und dient als Baustein für die Lipidbiosynthese von Nukleotiden und Nukleinsäuren.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 65-47-4
Sample solution is provided at 25 µL, 10mM.
Cytidine 5'-triphosphate (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. In the formation of phosphatidylcholine (PC), CTP reacts with phosphocholine, via CTP:phosphocholine cytidylyltransferases, to produce CDP-choline and diphosphate.[1],[2] This is the rate-limiting step in PC synthesis and, as a pivotal step in cell proliferation, can be important in cancer.[3] CTP also interacts with N-acylneuraminate, in a reaction mediated by N-acylneuraminate cytidylyltransferase, to generate an intermediate that is required for sialylation, namely CMP-N-acylneuraminic acid.[4]
Reference:
[1]. Li, Z., and Vance, D.E. Phosphatidylcholine and choline homeostasis. Journal of Lipid Research 49, 1187-1194 (2008).
[2]. Lagace, T.A., and Ridgway, N.D. The role of phospholipids in the biological activity and structure of the endoplasmic reticulum. Biochim.Biophys.Acta. 1833, 2499-2510 (2013).
[3]. Arsenault, D.J., Yoo, B.H., Rosen, K.V., et al. ras-Induced up-regulation of CTP:phosphocholine cytidyltransferase a contributes to malignant transformation of intestinal epithelial cells. The Journal of Biological Chemisty 288(1), 633-643 (2013).
[4]. Vionnet, J., Concepcion, N., Warner, T., et al. Purification of CMP-N-acetylneuraminic acid synthetase from bovine anterior pituitary glands. Glycobiology 9(5), 481-487 (1999).
Average Rating: 5
(Based on Reviews and 29 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *