CAY10595 |
| Katalog-Nr.GC18678 |
CAY10595 ist ein potenter Antagonist des CRTH2/DP2-Rezeptors, der mit einem Ki von 10 nM an den menschlichen Rezeptor bindet.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 916047-16-0
Sample solution is provided at 25 µL, 10mM.
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The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10595, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 10 nM. The R enantiomer of CAY10595 is significantly more potent exhibiting Ki values of 5.3 and 5 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 7.3 nM.
Review for CAY10595
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
Review for CAY10595
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